Biochemistry: USMLE Question No. 3

[Cardiac Arrest]

3. A patient with end-stage renal disease who is undergoing hemodialysis has normocytic normochromic anemia. Which of the following is the most appropriate therapy?

(A) Erythropoietin
(B) Ferrous sulfate
(C) Folic acid
(D) Vitamin B6 (pyridoxine)
(E) Vitamin B12 (cyanocobalamin)

[aTHoB]

Asslam Alikom

A) Erythropoietin

used in pt. with normocytic noromochoromic anaemia if the kidneys are affected because they are the main source of erythropoietin


B) Ferrous sulfate

used with micocytic hypochromic anaemia


(C) Folic acid
(D) Vitamin B6 (pyridoxine)

with macrocytic megaloplastic anaemia

so, my answer is (A)

i hope it is right one


:s:

[moon light]

I chooose ERYTHROPOITIN

the reason as athob mention it

[Khajool]

I agree with aTHoB

ERYTHROPOIETIN

[dr-kenzy]

salam ,,

i also agree with aTHoB

(A) Erythropoietin

[GoldenButterfly]

erythropoitin i agree

but vit B12 or folic acid could be used in megaloblastic anemia depending on which one is deficient


vitB6 is a blank space in my memory right now

[BaBiNa]

Salam Sweet Members

I agree .. answer is A


Erythropoietin is very effective but expensive ttt 4 the anemia of CRF and

has largely replaced repated blood transfusions.

[Cardiac Arrest]

The correct answer is A. Erythropoietin is a natural human hormone produced for therapeutic use using recombinant DNA technology. Its main effect is stimulation of red blood cell production by the bone marrow. Erythropoietin is produced in the kidneys; chronic renal failure is often accompanied by normocytic normochromic anemia, which can be treated with erythropoietin.

Ferrous sulfate (choice B) provides iron, an essential component of hemoglobin, myoglobin, and a number of enzymes in the body. This agent is indicated in the treatment of iron deficiency anemia, a microcytic, hypochromic anemia.

Folic acid (choice C) is required for nucleoprotein synthesis and maintenance of normal erythropoiesis. Deficiency results in a macrocytic, rather than a normocytic, anemia.

Vitamin B6 (pyridoxine; choice D) acts as a coenzyme in the metabolism of protein, carbohydrates, and fatty acids. Deficiency of this vitamin is associated with the development of anemia in several hereditary disorders, but it is not involved in the anemia of chronic renal failure.

Vitamin B12 (cyanocobalamin) (choice E) is essential for cell growth, cell
reproduction, and hematopoiesis. Deficiency produces megaloblastic anemia, a type of macrocytic anemia.