Pharmacology: USMLE Q No. 12

[Cardiac Arrest]

A 62-year-old woman being treated for hypertension and severe rheumatoid arthritis with multiple drugs is found to have proteinuria during a routine check-up. Which of the following drugs is most likely to be the cause of this finding?

A. Atenolol
B. Enalapril
C. Hydrochlorothiazide
D. Hydroxychloroquine
E. Ketoprofen

[MAJ]

The answer is E ==> Ketoprofen ==> used for RA


With a long term use can be a drug induced nephropathy

[Cardiac Arrest]

Option E (Ketoprofen) is correct. Long-term use of ketoprofen in high doses can cause renal disease, including interstitial nephritis, nephrotic syndrome, hematuria, proteinuria, azotemia, and renal papillary necrosis.

Option A (Atenolol) is incorrect. This does not cause renal dysfunction.

Option B (Enalapril) is incorrect. This does not cause renal dysfunction. In fact, enalapril is often used to prevent proteinuria associated with diabetic nephropathy.

Option C (Hydrochlorothiazide) is incorrect. This does not cause renal dysfunction.

Option D (Hydroxychloroquine) is incorrect. This does not cause renal dysfunction.

[H@SSOOM]

it was very interesting, thanx

[alva]

good question and thanks for the explanation