FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis

[lab_spe]

FibroTest-ActiTestTM (FT/AT) is a non-invasive alternative to liver biopsy which has been
clinically validated for patients with chronic hepatitis (B and C), alcoholic liver disease
(ALD) and non-alcoholic fatty liver disease (NAFLD). It uses an algorithm to combine the
results of serum tests of α2-macroglobulin, haptoglobin, apolipoprotien A1, total bilirubin,
gamma glutamyltranspeptidase (GGT) and alanine aminotransferase (ALT) to assess the level
of fibrosis and necro-inflammatory activity. There are several cross-sectional, retrospective
and prospective studies assessing the accuracy of FT/AT compared to liver biopsy. Trial
results support FT/AT as an alternative or complement to liver biopsy.

Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
http://gut.bmj.com/cgi/content/abstract/55/3/403

[Haitham]

FT/AT test is really usefel and I thaink it help in follow up and prognosis of the illness. It is the first time I know about this test. However, we have to know about this study furthermore. It is statisticly significant but is it clliniclly signifcant or not we need to know about that.
lab_spe thanx for your effort.

[lab_spe]

thanks Hitham
this subject is new that way i liked every one to read about it, enshallah there gonna be a presentation in Al Noor hospital about this subject and its is a very powerfull study supported by many abstracts, however i really dont know if any of our hospitals started to use it yet.

here r some of abstracts:

Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16542291&query_hl=1&itool=pubmed_docsum

Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16503961&query_hl=1&itool=pubmed_docsum

Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15685546&query_hl=1&itool=pubmed_docsum

[Haitham]

Hi

Thank you (lab_spe) for reply and extra information and abastract I will look for it.

Good luck.

[محمد الريفي]

الله يعطيكِ ألف عافيه

مجهود رائع ..تشكرين عليه

[sohel]

this test is new for the medical graduates in Bangladesh. We never heard of it to be done in practically.

[شيخ المختبر]

thanxxxxxxxx